Responsable(s)
DIRECTRICE - Fabiola TERZI à partir du 01/01/2020
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Etablissements. |
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CNRS - Centre national de la recherche scientifique (UMR 8253)
(établissement tutelle à
partir de 2014)
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INSERM - Institut national de la sante et de la recherche medicale (U 1151)
(établissement tutelle à
partir de 2014)
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U PARIS Cité - Université Paris Cité (UM 111)
(établissement tutelle à
partir de 2020)
Etablissement référent
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Adresse
Faculté de médecine Necker - 156-160 Rue de Vaugirard
75015 PARIS
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Contact
courriel : u1151-direction@inserm.fr
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| Site web :
https://www.institut-necker-enfants-malades.fr/index.php
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| Taille en ETP (sans compter les stagiaires):
supérieure à 50.
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Descriptif :
The Institut Necker-Enfants Malades (INEM), created in January 2014, is an international biomedical research centre located on the Necker campus, supported by the INSERM, CNRS, and the University Paris Descartes.
Research at INEM is focusing on common diseases caused by the interplay of polygenic inheritance and environmental factors. These diseases primarily affect children and the young adults, and encompass among others (auto)immune disorders, haematological diseases, infectious diseases, kidney diseases, cystic fibrosis and endocrinological disorders. The INEM teams apply insights obtained through basic and clinical research to develop innovative diagnostic and therapeutic strategies. The close interaction between the research labs and the clinical departments of the Necker Hospital is one of our major strengths which creates a highly dynamic environment and promotes translational and "bench to bedside" activities.
The 17 research teams of the INEM are grouped in two Departments:
I. The " Growth and Signalling " Department explores the growth and metabolic adaptations in a number of human (patho)physiological conditions, including chronic kidney diseases, cancer, mitochondrial diseases, and other growth and signalling-related diseases. In a close collaboration with the Necker Hospital, the group leaders apply their internationally recognized knowledge on the fundamental biological processes of cell cycle, autophagy, mitochondrial dynamics, hormone-growth factor-nutrient signal transduction and transcriptional networks.
II. The I2H department brings together immunologists, microbiologists and hematologists who have a strong track record in major fields such as normal and pathological B and T cell differentiation, autoimmunity, immune regulation and therapy, antigen presentation, and pathogenesis of systemic infections.
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| Année de création :
2014
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| Mission de la structure :
Recherche
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| Mode de gestion de la structure :
Non renseigné.
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| SIRET de la structure :
Non renseigné.
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Classement scientifique ERC
- LS6 : Immunity, Infection and Immunotherapy : The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
- LS3 : Cellular, Developmental and Regenerative Biology : Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
- LS1 : Molecules of Life: Biological Mechanisms, Structures and Functions : Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
- LS4 : Physiology in Health, Disease and Ageing : Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, inter-organ and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases))
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Domaine scientifique
- 5 : Biologie, médecine et santé 2014 0
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Ecole(s) doctorale(s) de rattachement
Non renseigné
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Rattachée au(x) programme(s) LOLF suivant(s):
- prg150-06 : Recherche universitaire en sciences de la vie, biotechnologies et santé
- prg172-05 : Recherches scientifiques et technologiques en sciences de la vie, biotechnologies et santé
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Rattachée au(x) thème(s) de recherche suivant(s):
BIOLOGIE CELLULAIRE, CROISSANCE ET SIGNALISATION, IMMUNOLOGIE, HÉMATOLOGIE, INFECTIOLOGIE;
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Origine de la structure
fusion en 2014 de :
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200412803D - CYTOKINES, HEMATOPOIESE ET REPONSE IMMUNE
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200616448G - DEVELOPPEMENT DU SYSTEME IMMUNITAIRE
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201019022M - CENTRE DE RECHERCHE CROISSANCE ET SIGNALISATION
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201019099W - DIFFERENCIATION ET PHYSIOLOGIE DES LYMPHOCYTES T
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201019119T - TOLÉRANCE IMMUNITAIRE ET PRÉSENTATION ANTIGÉNIQUE : IMPACT EN AUTO-IMMUNITÉ ET EN TRANSPLANTATION
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201019124Y - UNITE DE PATHOGENIE DES INFECTIONS SYSTEMIQUES
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200616465A - DIAGNOSTIC DES MALADIES GENETIQUES PAR L'ANALYSE DE LA SIGNALISATION CALCIQUE ET DES CELLULES FOETALES CIRCULANTES
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Liens avec d'autres structures :
Aucun.
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Site ESR :
Aucun.
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Fiche mise à jour par Alexandre Fabrer le 18/12/2020 à 15:37
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